AROUND AND BEYOND THE JOINT

Recent decades have witnessed the increase of knowledge about uncovered biological and cellular mechanisms regulating the pathogenetic steps of chronic inflammation with the identification of key molecules included in novel therapeutic management algorithms. Recent advances showed that many detrimental events characterizing the pathogenesis of immune- mediated diseases such Psoriatic Arthritis and Spondyloarthritis, or systemic autoimmune disorders such as Rheumatoid Arthritis, Systemic Sclerosis and Systemic Lupus Erythematosus might take place in different biological compartments far from the joint (e.g. mucosal surface from the oral cavity to the colonic mucosa, bone marrow and lung). In addition, periarticular organs such as the enthesis were demonstrated to host crucial pathogenetic events that are fundamental for the development of joint diseases, supporting the mandatory need to include them within the multiorgan view of such conditions.
Therefore, immune-mediated and systemic autoimmune diseases seem characterized by a multi- organ involvement affecting patient inter-individual heterogeneity in terms of disease trajectory prognosis as well as of therapeutic response.
During 2 days, internationally renowned experts in the field of rheumatology and immunology will discuss recent advances and unmet medical needs to refine a scientific research agenda to guide clinical and experimental studies in rheumatic diseases.

Friday 13th October
08.00-08.45 Registration of participants
08.45-08.50 Welcome and opening - Gian Domenico Sebastiani / Maria Antonietta D’Agostino
LUNG AND HEART MICROENVIRONMENT: WHAT DRIVES INFLAMMATION?
Chairpersons: Gian Domenico Sebastiani / Fabrizio Conti
08.50-09.10 Inflammatory mechanisms breaking pulmonary homeostasis in interstitial lung diseases - Roberto Caricchio
09.10-09.30 Molecular and cellular players of cardiac involvement in Systemic Sclerosis - Giacomo De Luca
09.30-09.50 Lipodomics and cardiovascular risk in Psoriatic Disease - Kurt de Vlam
09.50-10.10 Prognosis of pulmonary function progression in Systemic Sclerosis: implications for therapeutic approaches - Silvia Laura Bosello
10.10-10.30 Discussion
10.30-11.00 Coffee break
STARLIGHT SESSION 1
Chairpersons: Maria Sole Chimenti / Félicie Costantino
11.00-11.10 Multi Spectral Optoacustic Tomography in Psoriatic Disease - Filippo Fagni
11.10-11.20 Inflammation and bone loss: the brain control? - Renee van der Cruyssen
11.20-11.30 Emerging pathways in the pathogenesis of spondyloarthritis - Daniele Mauro
11.30-11.40 Discussion
UNCOVERED ASPECTS OF INFLAMMATION AND REPAIR
Chairpersons: Stefano Alivernini / Roberto Caricchio
11.40-12.00 Tendon repair and Inflammation: the egg or the hen? - Dirk Elewaut
12.00-12.20 Synovial and cartilage networks in Osteoarthritis progression - Jérémie Sellam
12.20-12.40 Molecular evolution of neutrophils in arthritis - Ricardo Grieshaber-Bouyer
12.40-13.00 Discussion
13.00-14.30 Lunch
MICROBIOLOGICAL MICROENVIROMMENT IN INFLAMMATORY DISEASES: BREAKING BAD?
Chairpersons: Adam Croft / Angelo Zoli
14.30-14.50 Infectious agents in the critical interface of the immunological tolerance loss - Maurizio Sanguinetti
14.50-15.10 Vaginal microbiome plays a role in gender difference manifestations in Spondyloarthritis? - Francesco Ciccia
15.10-15.30 Microbiome and fecal transplantation in Spondyloarthritis and Rheumatoid Arthritis: myth or reality? - Maxime Breban
15.30-15.50 Post-translational modifications in the pathogenesis of chronic inflammation - Fabrizio Conti
15.50-16.10 Discussion
16.10-16.40 Coffee break
STARLIGHT SESSION 2
Chairpersons: Georg Schett / Silvia Laura Bosello
16.40-16.50 Comprehensive characterization of serum extracellular vesicles in progressive scleroderma interstitial lung disease - Enrico De Lorenzis
16.50-17.00 An organoids-based approach to model the gut-joint axis in Spondyloarthritis - Gerlando Natalello 
17.00-17.10 The “leaky gut” in SpA: focus on a new pathomechanism related to ZEB proteins - Chiara Rizzo
17.10-17.20 Discussion
17.20-17.30 WRAP-UP DAY 1 AND CLOSING REMARKS - Maria Antonietta D’Agostino

Saturday 14th October
STROMAL AND MESENCHYMAL CELLS COMPARTMENTS WITHIN AND AROUND THE JOINT
Chairpersons: Maxime Breban / Roberto Giacomelli
08.30-08.50 Tendon and enthesial microenvironment in Psoriatic Arthritis inflammation - Andreas Ramming
08.50-09.10 Heterogeneity of synovial fibroblast networks regulating arthritis severity - Adam Croft
09.10-09.30 Dissecting tenosynovial microenviroment in the pre-clinical phase of Rheumatoid Arthritis - Stefano Alivernini
09.30-09.50 Mesenchymal cell niche of lymph nodes in Rheumatoid Arthritis - Lisa Van Baarsen
09.50-10.10 Discussion 
10.10-10.40 Coffee Break
RESTORE IMMUNITY: NEW INSIGHTS FROM THE CAR-T CELL APPROACH
Chairpersons: Jérémie Sellam / Dirk Elewaut
10.40-11.00 Novel approaches of CAR T-cell therapy in solid tumours and hematological malignancies - Franco Locatelli
11.00-11.20 Deconvolution of the antibody’s response in CAR-T cell treated autoimmune patients - Georg Schett
11.20-11.40 Unmet clinical and therapeutic needs in CAR-T cells-based approach - Ruggero De Maria
11.40-12.00 Discussion
STARLIGHT SESSION 3
Chairpersons: Francesco Del Galdo / Andreas Ramming
12.00-12.10 Cardiovascular risk in rheumatic diseases: implications and challenges - Hélène Gouze
12.10-12.20 Measuring Fibroblast activation in systemic sclerosis patients in vivo - Christina Bergmann
12.20-12.30 Contextual factors in spondyloarthritis: from mice to humans - Barbara Neerinckx
12.30-12.40 Discussion
12.40-14.00 Lunch
DISSECTING NOVEL CLINICAL, IMAGING AND GENETIC-BASED APPROACHES FOR STRATIFICATION OF PATIENTS IN CHRONIC INFLAMMATORY DISEASES
Chairpersons: Kurt de Vlam / Roula Said-Nahal
14.00-14.20 Rheumatoid arthritis: risk phenotypes and strategies for prevention, diagnosis and therapeutic approaches - Andrew Cope
14.20-14.40 The genetic landscape of immune mediated diseases: from genotype to phenotype - Félicie Costantino
14.40-15.00 Machine learning algorithms for patient stratification in Systemic Lupus Erythematosus for therapeutic approaches - Augusta Ortolan
15.00-15.20 Discussion
PATHOPHYSIOLOGICAL INSIGHTS TO DETECT DISEASE TRAJECTORY IN CHRONIC INFLAMMATION AND CANCER
Chairpersons: Georg Schett / Andrew Cope
15.20-15.40 Tuning fibrosis: Lessons from reverse translation studies on progressing vs. non progressing patients - Francesco del Galdo
15.40-16.00 The link between inflammation and melanoma: a post-translational modification? - Ketty Peris
16.00-16.20 Cellular and molecular pathways in atopic dermatitis - Andrea Chiricozzi
16.20-16.40 Discussion
16.40-17.10 Farewell Coffee Break
17.10-17.30 WRAP-UP DAY 2 AND CLOSING REMARKS - Maria Antonietta D’Agostino
17.30-17.45 Discussion and compilation of CME questionnaire